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KMID : 1094020130300060478
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Journal of Veterinary Clinics
2013 Volume.30 No. 6 p.478 ~ p.481
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Peripheral Giant Cell Granuloma in a Dog
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Cho Eun-Sang
Jeon Sung-Joo
Hong Da-Hae
Jung Ju-Young
Park Bae-Keun
Son Hwa-Young
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Abstract
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A mass was detected in the oral cavity from a 18-year-old female miniature poodle dog. Grossly, the mass was soft to hard, red to purple, and 1.5 × 1.5 × 1 cm in size. Histopathologically, the mass was composed of hyperplastic gingival epithelium, well-vascularized stroma, closely packed pleomorphic cells, and numerous giant cells with multiple nuclei and abundant eosinophilic cytoplasm. Immunohistochemically, tumor cells were positive for alkaline phosphatase and cytokeratin 7, but not positive for CD68 unlike in human. The mass was diagnosed to peripheral giant cell granuloma in oral cavity through typical clinical and histopathological features.
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KEYWORD
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peripheral giant cell granuloma, canine, alkaline phosphatase, cytokeratin 7, CD68
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